Thermo Fisher Scientific USP15 Polyclonal Antibody
Human USP15 단백질을 인식하는 Goat Polyclonal Antibody로, IHC(P)에서 2.5–3.8 µg/mL 농도로 사용 가능. 0.5 mg/mL 농도의 액상형 제품이며, TBS(pH 7.3) + 0.5% BSA, 0.02% sodium azide 포함. -20°C 보관, 연구용 전용.
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- PA5142062
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–3.8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence NDIENENCMHTN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932724 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination, catalyzed by deubiquitinating enzymes, provides an additional level of ubiquitin regulation. These enzymes fall into four distinct families:
- Ubiquitin C-terminal hydrolases
- Ubiquitin-specific processing proteases (USPs)
- OTU-domain ubiquitin-aldehyde-binding proteins
- Jab1/Pad1/MPN-domain-containing metallo-enzymes
Among these, USPs are the most widespread deubiquitinating enzymes across evolution. They release ubiquitin from conjugated proteins and share conserved catalytic domains containing Cys and His boxes, with variable terminal extensions that influence substrate recognition and protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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