Thermo Fisher Scientific HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)
HLA-DR/DP/DQ 인식용 재조합 Rabbit Monoclonal 항체로 다양한 면역분석(WB, IHC, ICC, Flow 등)에 적용 가능. HEK293 발현 시스템 기반, 고순도 Protein A/G 정제. 인간 시료 반응성, 비보존액 PBS 용액 형태로 -20°C 이하 보관.
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- RBM1-2967-P1ABX
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Thermo Fisher Scientific HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HLA-Pan, 2967R |
| Immunogen | Non-T, non-B human acute lymphoblastic leukemia REH6 cell line |
| Target Family | HLA-DR/DP/DQ |
| UniProt IDs | P01911-1, P01920-1, P04440-1 |
| Antigen Range | 1–266, 1–261, 1–258 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Direct ELISA: For coating, use antibody at 2–5 µg/mL.
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Formalin-fixed tissues: Heat sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, then cool at room temperature for 20 min.
Target Information
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating immune responses.
HLA and MHC antibodies are essential tools in Immunopeptidomics, aiding in the identification and characterization of neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
제품 이미지
(이미지 파일: RBM1-2967-P1ABX_HLA-DRDPDQ_P01911-1_Rabbit.svg, RBM1-2967-P1ABX_HLA-DRDPDQ_P01911-1_Rabbit_PDP.jpeg, RBM1-2967-P1ABX_HLA-DRDPDQ_P01920-1_Rabbit.svg, RBM1-2967-P1ABX_HLA-DRDPDQ_P01920-1_Rabbit_PDP.jpeg, RBM1-2967-P1ABX_HLA-DRDPDQ_P04440-1_Rabbit.svg, RBM1-2967-P1ABX_HLA-DRDPDQ_P04440-1_Rabbit_PDP.jpeg)
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