Thermo Fisher Scientific CD21 Monoclonal Antibody (CC21), FITC
소, CD21 항원을 인식하는 Mouse IgG1 단클론 항체로 FITC 형광표지. 유세포분석(Flow Cytometry)에 적합하며, 498/517 nm에서 여기/방출. 단백질 A로 정제되어 PBS 및 BSA 버퍼에 보관. 4°C 단기, -20°C 장기 보관 권장.
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Thermo Fisher Scientific CD21 Monoclonal Antibody (CC21), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
Publications: Reference available upon request
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC21 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745282 |
Additional Formats
- Unconjugated: MA5-28323
- PE conjugate: MA5-28320
- Custom conjugation available upon request
Product Specific Information
Mouse anti-Bovine CD21 monoclonal antibody, clone CC21 recognizes the bovine CD21 cell surface antigen, an approximately 145 kDa single-pass type I membrane glycoprotein containing multiple sushi domains.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigens.
CD21 plays important roles in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of humoral responses to T-dependent antigens
Additionally, CD21 serves as a receptor for Epstein-Barr virus and contributes to prion targeting to follicular dendritic cells, facilitating neuroinvasion following peripheral exposure.
A soluble form (sCD21) is shed from lymphocyte surfaces and retains ligand-binding ability.
CD21 interacts with complement components (C3d, C3dg, iC3b), EBV, and IFNα, and associates with CD23, CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
Genetic variations in CD21 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternative splicing generates different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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