Thermo Fisher Scientific ALK Monoclonal Antibody (3E12)
인간 ALK 단백질을 인식하는 Mouse IgG2b 단클론 항체로, ELISA에 사용 가능. 합성 펩타이드를 면역원으로 제작되었으며, Affinity chromatography로 정제됨. 뇌 발달 및 종양 연구용으로 적합. 연구용 시약으로만 사용.
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Applications
ELISA (ELISA)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E12 |
| Immunogen | A synthetic peptide corresponding to human ALK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TPQWQVRTLK DARFQDHQDH C
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene consisting of ALK and nucleophosmin (NPM). The NPM-ALK fusion gene product is oncogenic. ALK encodes a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, absent in the NPM-ALK fusion product. ALK shows high sequence similarity to LTK and plays an important role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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