Thermo Fisher Scientific KRT84 Monoclonal Antibody (OTI2D1), TrueMAB

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The Keratin multigene family includes “soft” epithelial cytokeratins and “hard” hair keratins.

• Epithelial keratins contribute to epithelial layering and structure.
• Hair keratins form nails and hair.

Keratin 84 (KRT84, also known as HB4 or KRTHB4) is a 600 amino acid, basic/neutral type II keratin expressed in hair follicles.
It heterodimerizes with type I keratins to form hair and nails.
The KRT84 gene is located on human chromosome 12, which encodes over 1,100 genes (~4.5% of the human genome) and is associated with various diseases such as hypochondrogenesis, achondrogenesis, and Kniest dysplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.