Thermo Fisher Scientific WNT4 Polyclonal Antibody
WNT4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 10–15 µg/mL 농도로 사용 가능. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS에 0.1% sodium azide 포함, 4°C 또는 -20°C에서 보관. 연구용으로만 사용.
- 카탈로그번호
- PA534324
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 10–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from internal region of human WNT4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551676 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Bovine, Dog, Horse, Pig (100%)
Elephant (94%)
Opossum (88%)
Target Information
The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins are implicated in oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis.
WNT4 is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein with 98% amino acid identity to the Wnt4 protein of mouse and rat. WNT4 and a nuclear receptor antagonizing the testis-determining factor play a concerted role in female development and prevention of testes formation.
Additionally, WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and SERKAL syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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