Thermo Fisher Scientific TEK Polyclonal Antibody
TEK 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 적용 가능하며, endothelial cell 연구 및 혈관 발달 관련 신호전달 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
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Applications
- Western Blot (WB): Assay-dependent
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of human, mouse, rat, bovine, and predicted chimpanzee Tie2 proteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533527 |
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing TIE2 are quiescent and antiapoptotic, comprising a side population that adheres to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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