Thermo Fisher Scientific PPAR alpha Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1–3 µg/mL

Product Specifications

Target Information

Peroxisome proliferators are non-genotoxic carcinogens that exert their effects through interaction with nuclear hormone receptors known as peroxisome proliferator-activated receptors (PPARs). These receptors are ligand-dependent intracellular proteins that regulate transcription of specific genes by binding to DNA sequences after activation by appropriate ligands.

PPARs are activated by compounds such as clofibric acid, nafenopin, WY-14,643, and certain fatty acids. They can induce transcription of acyl coenzyme A oxidase and cytochrome P450 (CYP450) A6 through specific response elements. PPARs, like other nuclear hormone receptors, form heterodimers with retinoid X receptor (RXR) alpha.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.