Thermo Fisher Scientific TBX3 Polyclonal Antibody
TBX3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ELISA 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 개발 과정 연구 및 발달 생물학 연구에 적합합니다.
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- 424800
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 12 publications |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 4 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
| ELISA | 1:1,000 | – |
| Immunoprecipitation (IP) | Assay-dependent | – |
| ChIP assay (ChIP) | – | View 2 publications |
| Miscellaneous (PubMed) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from an internal region of human T-box 3, differing from mouse and rat by one conservative and one non-conservative amino acid |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533526 |
Product Specific Information
Catalog No. 42-4800 has been successfully used in immunohistochemistry analysis of Tbx3 in mouse E16.5 frozen lung sections.
Target Information
T-box 3 (TBX3) is a member of a conserved gene family sharing a common DNA-binding domain, the T-box. These genes encode transcription factors that regulate developmental processes.
Tbx3 functions as a transcriptional repressor binding to canonical Brachyury binding sites and plays a role in anterior/posterior axis formation of the tetrapod forelimb. It is essential for normal mammary development and is implicated in tumorigenesis.
Tbx3 expression increases during osteoblast differentiation and may influence osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, gland, tooth, hair, and genital development.
Alternative splicing generates three transcript variants encoding different isoforms. Overexpression of Tbx3 has been observed in certain human breast cancer cell lines and can induce immortalization in mouse embryo fibroblasts. Truncated forms of Tbx3 are elevated in plasma samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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