Thermo Fisher Scientific CD354 (TREM-1) Monoclonal Antibody (L5-B8.2A12.3A12), FITC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-dependent

-

Product Specifications

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

L5-B8.2A12.3A12

Immunogen

Mouse TREM-1 Fc fusion protein

Conjugate

FITC FITC FITC

View additional formats

• Unconjugated
• PE
• Request custom conjugation

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Shipping conditions

Wet ice

RRID

AB_2745190

Product Specific Information

Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes.

Target Information

TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.