Thermo Fisher Scientific MPP8 Polyclonal Antibody
Rabbit polyclonal antibody against human MPP8 protein. Validated for WB and IHC applications. Recognizes methylated H3K9 and involved in epigenetic repression. Lyophilized form; reconstitute in sterile water. For research use only.
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- OSM00128W-100UL
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 450–500 of human MPP8 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: MPP8.
Target Information
MPP8 is a heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me), promoting recruitment of proteins mediating epigenetic repression. It mediates recruitment of the HUSH complex to H3K9me3 sites, maintaining transcriptional silencing by promoting SETDB1 recruitment and H3K9me3 deposition. MPP8 also recruits DNMT3A for DNA methylation at CpG sites, down-regulates CDH1 expression, and represses L1 retrotransposons in collaboration with MORC2 and SETDB1. The HUSH complex further silences unintegrated retroviral DNA via ZNF638 recruitment.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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