Thermo Fisher Scientific CRX Monoclonal Antibody (4A12)
CRX 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, ICC/IF, ELISA에 사용 가능. 인간 시료에 반응하며, Mouse IgG2b 형식. PBS 용액 상태로 제공되며, -20°C에서 보관. 시각 관련 유전자 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A12 |
| Immunogen | CRX (AAH16664, 1–299 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGG QAKARPAKRK AGTSPRPSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP TSLSGQSYGA YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that regulates the expression of multiple photoreceptor genes in the developing retina, including opsin and rhodopsin. CRX binds the OTX motif (TAATCC/A) upstream of photoreceptor genes and is also expressed in pinealocytes, potentially controlling melatonin synthesis and circadian rhythm regulation.
Mutations in the CRX gene are associated with visual disorders such as cone-rod dystrophy (CORD2), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All known mutations cause disease in heterozygotes, with missense mutations affecting the homeobox domain and frameshift mutations impacting the OTX domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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