Thermo Fisher Scientific FGFR2 Monoclonal Antibody (OTI3B3), TrueMAB

Applications

• Western Blot (WB): 1:200–1:1,000

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

FGFR2 is a member of the FGFR family of receptor tyrosine kinases that regulate key cellular functions such as:

• Angiogenesis
• Mitogenesis
• Osteogenesis
• Myogenesis
• Carcinogenesis
• Cellular differentiation
• Tissue repair after injury

The FGFR family is implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Mutations in FGFR2 are associated with:

• Crouzon syndrome
• Pfeiffer syndrome
• Craniosynostosis
• Apert syndrome
• Jackson-Weiss syndrome
• Beare-Stevenson cutis gyrata syndrome
• Saethre-Chotzen syndrome
• Syndromic craniosynostosis

Multiple alternatively spliced transcript variants encoding different isoforms have been noted.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.