Thermo Fisher Scientific Rb Monoclonal Antibody (1F8 (Rb1)), Biotin
Rb 단백질을 표적하는 Thermo Fisher Scientific의 Biotin 결합 단일클론 항체로, Human과 Mouse에 반응합니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합하며, Protein G로 정제된 고품질 항체입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Rb Monoclonal Antibody (1F8 (Rb1)), Biotin
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 5 publications |
| Immunohistochemistry (IHC) | – | View 11 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | View publications |
| Immunocytochemistry (ICC/IF) | 1:10–1:200 | View 1 publication |
| Flow Cytometry (Flow) | Assay-dependent | View publications |
| Immunoprecipitation (IP) | 2 µg/mL | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F8 (Rb1) |
| Immunogen | Recombinant human Rb protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979886 |
Additional Formats
Product Specific Information
MA5-11384 targets Retinoblastoma (Rb) in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human and Mouse samples.
The immunogen used is recombinant human Rb protein.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues but not on tyrosine. Rb forms complexes with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E proteins.
Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth.
Aberrations in the RB gene have been implicated in cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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