Thermo Fisher Scientific CD2 Monoclonal Antibody (AB75)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-11373 targets CD2 in IHC (P) and FACS applications and shows reactivity with human samples.
The immunogen is a recombinant fragment encoding the external domain of the human CD2 protein.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage, expressed on all peripheral blood T cells.
It is one of the earliest T-cell markers, present on over 95% of thymocytes, and also found on some natural killer cells but not on B lymphocytes.

Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2 acts as or associates with the erythrocyte receptor.
The CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells.
Although CD2–CD58 affinity in solution is low, it is compensated within the cell–cell interface to provide tight adhesion.
T-cell activation increases CD2 expression and mobility, facilitating CD2–CD58 contact and strengthening intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and aids infection control.
Diseases associated with CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymic absence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.