Thermo Fisher Scientific BMI-1 Recombinant Rabbit Monoclonal Antibody (1F2)
BMI-1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(Paraffin) 분석에 적합. 인간 시료 반응성, HEK293 발현 시스템 사용. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적 저장 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1F2 |
| Immunogen | A synthesized peptide derived from human Bmi1 (amino acids 311–325) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898303 |
Product Specific Information
This antibody has been tested in direct ELISA.
Target Information
Component of the Polycomb group (PcG) multiprotein PRC1 complex, which maintains transcriptional repression of many genes, including Hox genes, throughout development. The PRC1 complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, thereby altering chromatin expressibility. Within the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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