Thermo Fisher Scientific p14ARF Monoclonal Antibody (4C6/4)
인간 및 랫트 반응성 p14ARF 단클론 항체로 다양한 면역학적 분석에 사용 가능. Western blot, IHC, ICC/IF, Flow cytometry에 적합. 단일클론 Mouse IgG2a, kappa 형식이며, Protein A/G 정제된 액상 형태. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C6/4 |
| Immunogen | Recombinant full-length human p14ARF protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins: p16INK4a and the alternative reading frame protein ARF (p14ARF in human and P19ARF in mouse).
These proteins interact with upstream tumor suppressors, retinoblastoma protein and p53, respectively. Each plays a role in cellular senescence and activation of pathways involved in cell cycle control and tumor suppression.
p14ARF (or P19ARF in mouse) can induce G1 and G2 phase arrest in a p53-dependent manner. The functional differences between mouse and human ARF proteins may contribute to species-specific tumor susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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