Thermo Fisher Scientific P16INK4a Monoclonal Antibody (rCDKN2A/8004)
인간 p16INK4a 단백질을 인식하는 마우스 단클론 항체입니다. IHC(P) 및 IHC(PFA) 분석에 사용 가능하며, CDK4 억제 관련 연구에 적합합니다. 단백질 A/G로 정제된 액상 항체로, 4°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCDKN2A/8004 |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which function as inhibitors of CDK4 kinase. Another transcript encodes an alternate open reading frame (ARF) protein that stabilizes tumor suppressor p53 by interacting with and sequestering MDM2, preventing p53 degradation. Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product contribute to cell cycle G1 control. This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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