Thermo Fisher Scientific BCL2L15 Polyclonal Antibody
인간 BCL2L15 단백질을 인식하는 Rabbit Polyclonal 항체입니다. IHC(P)에서 1:50~1:200 희석 비율로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관되며, 세포사멸 관련 연구에 적합합니다.
- 카탈로그번호
- PA556242
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BCL2L15 (Product #RP-94532) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638507 |
Product Specific Information
Immunogen sequence:
CIVNTLLMDF LSPTLQVASR NLCCVDEVDS GEPCSFDVAI IAGRLRMLGD QFNGELEASA KNVIAETIKG
Antigen sequence identity:
- Mouse: 69%
- Rat: 73%
Target Information
Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, such as Bax, contain three of the four Bcl-2 homology regions (BH1–3), while BH3-only proteins, such as Bim, possess only the short BH3 motif.
Database searches revealed Bfk, a novel member of the Bcl-2 family that contains BH2 and BH3 regions but lacks BH1 and BH4. Bfk is closely related to Bcl-G(L), lacks a C-terminal membrane anchor, and is cytosolic. Overexpression of Bfk weakly promotes apoptosis and antagonizes Bcl-2’s prosurvival function.
Low expression levels of Bfk are found in stomach, ovary, bone marrow, and spleen, but increase markedly in the mammary gland during pregnancy, suggesting a role in mammary development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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