Thermo Fisher Scientific HBS1L Polyclonal Antibody

Thermo Fisher Scientific HBS1L Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
CITGKIEAGY IQTGDRLLAM PPNETCTVKG ITLHDEPVDW AAAGDHVSLT LVGMDIIKIN VGCIFCGPKV PIKACTRF

Highest antigen sequence identity to the following orthologs:

• Mouse: 95%
• Rat: 95%

Target Information

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues, with the highest expression in heart and skeletal muscle.
The intergenic region between this gene and the MYB gene has been identified as a quantitative trait locus (QTL) controlling fetal hemoglobin level. This region influences erythrocyte, platelet, and monocyte counts, as well as erythrocyte volume and hemoglobin content.
DNA polymorphisms in this region are associated with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E.
Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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