Thermo Fisher Scientific MYPT1 Polyclonal Antibody
Thermo Fisher Scientific MYPT1 Polyclonal Antibody는 인간 MYPT1의 Thr853 근처 비인산화 펩타이드로부터 제작된 토끼 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 액상 형태로 제공됩니다. -20°C 보관, 연구용 전용.
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- PA538300
- 판매단위
- pk
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human MYPT1 around the phosphorylation site of Thr853 (R-S-TP-G-V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554901 |
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. This enzyme regulates the interaction of actin and myosin downstream of the small GTPase Rho.
Active GTP-bound RhoA interacts with the myosin-binding subunit (MBS) of myosin phosphatase, controlling the phosphorylation of myosin light chain (MLC).
Rho-associated kinase (Rho-kinase), activated by GTP-RhoA, phosphorylates MBS and inactivates myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increases phosphorylation of MBS and MLC, suggesting Rho inhibits myosin phosphatase through Rho-kinase activity.
Several transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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