Thermo Fisher Scientific CD44 Recombinant Rabbit Monoclonal Antibody (BLR038F)

Applications and Tested Dilution

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 functions as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration.

It is involved in various cellular processes such as lymphocyte activation, recirculation, and homing. CD44 expression can be upregulated in certain carcinomas and may be associated with metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate its expression upon stimulation.

Transcripts for the CD44 gene undergo complex alternative splicing, resulting in multiple functionally distinct isoforms. These variants contribute to the structural and functional diversity of the CD44 protein. CD44 dysfunction has been linked to diseases such as superficial keratitis and lichen sclerosus and may play a role in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.