Thermo Fisher Scientific INSR beta Monoclonal Antibody (CT-3)
INSR beta 단백질을 인식하는 CT-3 단클론 항체로, Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human 및 Mouse 시료에 반응하며, Protein G로 정제된 액상형 항체. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:25–1:50 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | View 1 publication |
| ELISA | Assay-dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-3 |
| Immunogen | Recombinant fragment including the C-terminal 100 amino acid residues of human insulin receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536351 |
Product Specific Information
Staining of formalin-fixed paraffin-embedded tissue sections requires boiling the sections in 10 mM citrate buffer (pH 6.0) for 10–20 minutes, followed by cooling at room temperature for 20 minutes.
Target Information
The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence regions that confer ligand specificity and in intracellular signaling domains, resulting in distinct functional consequences. Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are critical in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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