Thermo Fisher Scientific INSR beta Monoclonal Antibody (CT-3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Staining of formalin-fixed paraffin-embedded tissue sections requires boiling the sections in 10 mM citrate buffer (pH 6.0) for 10–20 minutes, followed by cooling at room temperature for 20 minutes.

Target Information

The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence regions that confer ligand specificity and in intracellular signaling domains, resulting in distinct functional consequences. Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are critical in cancer development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.