Thermo Fisher Scientific FXR Monoclonal Antibody (A9033A)
FXR 단백질을 인식하는 마우스 단클론 항체로, 인간·마우스·랫에서 교차 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능하며, 냉장 또는 냉동 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 7 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 20–40 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 3 publications |
| ELISA | 0.2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A9033A |
| Immunogen | Baculovirus-expressed recombinant human FXR (2–126 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage Conditions | 2–8°C for up to 1 month; for long-term storage, store at -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2532196 |
Product Specific Information
This antibody specifically recognizes human FXR and cross-reacts with mouse and rat FXR.
Target Information
FXR (Farnesoid X Receptor; NR1H4) is a member of the nuclear receptor superfamily of ligand-activated transcription factors (NR1 subfamily). It acts as a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, and deoxycholic acid. FXR plays an essential role in bile acid homeostasis through the regulation of genes involved in bile acid synthesis, conjugation, and enterohepatic circulation. It also regulates lipid and glucose homeostasis and participates in innate immune response.
The FXR-RXR heterodimer binds predominantly to FXR response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' spaced by one nucleotide (IR-1), and with lower affinity to tandem repeat DR1 sites. FXR activation influences transcription of several genes involved in bile acid metabolism, conjugation, and transport, including NR0B2, CYP7A1, CYP8B1, SLC10A1/NTCP, SLC27A5/BACS, BAAT, ABCB11/BSEP, ABCC2/MRP2, and ABCB4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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