Thermo Fisher Scientific CLEC5A Polyclonal Antibody
CLEC5A 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody. Western blot, IHC, Flow cytometry 등 다양한 응용 가능. 인간 CLEC5A에 반응하며 항원 친화 크로마토그래피로 정제. 염결합 및 동결 방지 성분 포함, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 0.25 µg per million cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human MDL-1/CLEC5A (Tyr26–Lys188) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576926 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant mouse MDL-1 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CLEC5A functions as a positive regulator of osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. It regulates inflammatory responses and plays a key role in synovial injury and bone erosion during autoimmune joint inflammation. Additionally, it serves as a critical macrophage receptor for dengue virus serotypes 1–4. Binding of dengue virus to CLEC5A triggers TYROBP phosphorylation and proinflammatory cytokine release without viral entry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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