Thermo Fisher Scientific c-Myc Polyclonal Antibody
Thermo Fisher Scientific의 c-Myc Polyclonal Antibody는 인간 및 생쥐 시료에서 c-Myc 단백질 검출용으로 최적화된 다클론 항체입니다. Western blot과 ELISA에 적합하며, 핵 및 핵소체 내 c-Myc 발현 연구에 활용됩니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 347–439 of human c-Myc (NP_0013417991) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.44 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913765 |
Product Specific Information
- Positive test controls: HCT116, MCF7, NIH/3T3, Mouse liver
- Localization: Nucleus, nucleolus, nucleoplasm
Immunogen sequence:
LRQISNNRKC TSPRSSDTEE NVKRRTHNVL ERQRRNELKR SFFALRDQIP ELENNEKAPK VVILKKATAY ILSVQAEEQK LISEEDLLRK RRE
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays critical roles in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK
- Vasculogenesis and angiogenesis during tumor development
Amplification or translocation of the c-Myc gene is implicated in multiple human cancers, including lung, breast, colon carcinomas, and Burkitt’s lymphoma.
Antibodies recognizing c-Myc epitopes can detect overexpressed proteins with Myc tags fused to targeted proteins.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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