Thermo Fisher Scientific CIITA Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.

Target Information

CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats), and a GTP binding domain.
It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex (MHC) gene transcription, known as the “master control factor” for expression of these genes.
CIITA binds GTP and uses GTP binding to facilitate its transport into the nucleus. Once inside, it does not bind DNA directly but functions through intrinsic acetyltransferase (AT) activity in a coactivator-like manner.
Mutations in this gene have been associated with bare lymphocyte syndrome type II (hereditary MHC class II deficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.