Thermo Fisher Scientific CIITA Polyclonal Antibody
Rabbit polyclonal antibody targeting human CIITA protein. Validated for Western blot and ELISA applications. Supplied as liquid whole serum with 0.01% sodium azide. Recommended storage at -20°C, avoiding freeze/thaw cycles. For research use only.
- 카탈로그번호
- 100-401-192
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CIITA Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| ELISA | 1:5,000–1:25,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal end of the human CIITA gene conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 90 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
Target Information
CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats), and a GTP binding domain.
It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex (MHC) gene transcription, known as the “master control factor” for expression of these genes.
CIITA binds GTP and uses GTP binding to facilitate its transport into the nucleus. Once inside, it does not bind DNA directly but functions through intrinsic acetyltransferase (AT) activity in a coactivator-like manner.
Mutations in this gene have been associated with bare lymphocyte syndrome type II (hereditary MHC class II deficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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