Thermo Fisher Scientific Bestrophin 2 Polyclonal Antibody
Rabbit polyclonal antibody against Bestrophin 2 for IHC (paraffin) applications. Reacts with human, dog, and non-human primate. Antigen affinity purified, supplied in PBS with sodium azide. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P): 2.5–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from internal region of human BEST2 / Bestrophin-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550744 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Monkey, Marmoset, Dog: 100%
- Mouse, Hamster, Panda, Bovine: 93%
- Opossum: 87%
Target Information
Best2 forms calcium-sensitive chloride channels and is permeable to bicarbonate. The Best2 gene belongs to the bestrophin gene family of anion channels, sharing a conserved gene structure with distinct 3′ ends. Bestrophins are transmembrane proteins rich in aromatic residues, including an invariant arg-phe-pro motif.
Mutations in the Best2 gene are associated with vitelliform macular dystrophy. The gene is mainly expressed in the retinal pigment epithelium and colon.
Diseases associated with BEST2 include Vitelliform Macular Dystrophy and Bestrophinopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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