Thermo Fisher Scientific Aggrecan Neo Polyclonal Antibody
Aggrecan 단백질의 Neo-epitope를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC/IF 분석에 적합합니다. 다양한 종(Bovine, Human, Mouse 등)에 반응하며, aggrecanase 절단 생성물 검출에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 11 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 3 publications |
| Immunocytochemistry (ICC/IF) | – | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Pig, Rat |
| Published Species | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C G G N(387) I T E G E(392) of human aggrecan |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2242021 |
Product Specific Information
- PA1-1746 detects human, rat, mouse, bovine, canine, and porcine aggrecan neo G1.
- Successfully used in Western blot and immunofluorescence procedures.
- Detects a ~64 kDa protein representing the neoepitope sequence (NITEGE) generated by aggrecanase-mediated cleavage at Glu373-Ala374 of aggrecan core proteins.
- Immunogen: Synthetic peptide corresponding to residues C G G N(387) I T E G E(392) of human aggrecan.
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
It is a key structural component of the extracellular matrix in cartilage, providing resistance to compression.
The human protein (~250 kDa, 2316 amino acids) exists in multiple isoforms due to alternative splicing and exhibits a bottlebrush structure with chondroitin sulfate and keratan sulfate chains.
Aggrecan degradation is associated with cartilage deterioration in joint injury, disease, and aging.
The protein includes three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during osteoarthritis progression due to cleavage by aggrecanase and MMPs.
Antibodies BC-3 and BC-4 can detect neoepitopes generated by aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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