Thermo Fisher Scientific IGF1 Monoclonal Antibody (OTI3A5), TrueMAB
IGF1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. 고순도의 Affinity chromatography 정제 제품으로, 연구용으로 IGF1 관련 신호전달 연구에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–151 of human IGF1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IGF1 (Insulin-like Growth Factor 1) is structurally and functionally related to insulin, but exhibits higher growth-promoting activity. It induces cellular responses such as proliferation, differentiation, migration, and survival across various cell types in muscle, bone, and cartilage tissues.
IGF1 also enhances glucose transport and metabolism, acting as a potent activator of the AKT signaling pathway, which promotes proliferation and inhibits apoptosis.
Low IGF1 levels have been associated with Alzheimer's disease, and genetic defects in IGF1 can lead to growth factor deficiencies. Mature human IGF1 is 100% homologous with bovine and porcine IGF1 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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