Thermo Fisher Scientific SFTPC Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins, which include plasma proteins and apolipoproteins SPA, SPB, SPC, and SPD. The surfactant is secreted by alveolar cells of the lung and maintains pulmonary stability by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene cause pulmonary surfactant metabolism dysfunction type 2 (also known as pulmonary alveolar proteinosis due to surfactant protein C deficiency) and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.