Thermo Fisher Scientific CFTR VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1024)
CFTR 단백질을 인식하는 알파카 유래 재조합 단일클론 항체. ELISA에 적합하며 CHO 세포에서 발현됨. 1 mg/mL 농도의 액상 형태로 제공되며, 금속 킬레이트 크로마토그래피로 정제됨. 단기 4℃, 장기 -20℃ 보관 권장.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1024 |
| Immunogen | Recombinant Human CFTR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (ΔF508), resulting in abnormal chloride transport. The CF mutation often leads to lethal lung and liver disease. Interestingly, CFTR is also utilized by Salmonella typhi to enter intestinal epithelial cells, and ΔF508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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