Thermo Fisher Scientific CFTR VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1012)
Recombinant alpaca monoclonal antibody targeting human CFTR. Validated for ELISA applications. Expressed in CHO cells with 8His-Cys tag. High purity via metal-chelate chromatography. Suitable for research use only.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 상세 정보 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1012 |
| Immunogen | Recombinant Human CFTR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to defective chloride transport.
This mutation often results in severe lung and liver disease. Interestingly, CFTR also serves as an entry point for Salmonella typhi into intestinal epithelial cells, and studies show ΔF508 heterozygote and homozygote mice exhibit 86% and 100% reductions, respectively, in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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