Thermo Fisher Scientific CHMP4B Polyclonal Antibody
Thermo Fisher Scientific CHMP4B Polyclonal Antibody는 인간 CHMP4B 단백질을 인식하는 Rabbit IgG 폴리클로날 항체입니다. Western blot, IHC, Flow cytometry에 적합하며 KLH 접합 합성 펩타이드로 면역생성되었습니다. ESCRT-III 복합체 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 51–79 amino acids from the N-terminal region of human CHMP4B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544036 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, Xenopus, and zebrafish based on sequence homology.
Target Information
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. It is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in sorting endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also plays a role in cytokinesis and in the budding of enveloped viruses such as HIV-1.
CHMP4 proteins interact with PDCD6IP (ALIX) and assemble into membrane-attached filaments that form circular scaffolds, promoting or stabilizing outward budding and generating luminal vesicles of multivesicular bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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