Thermo Fisher Scientific ATF5 Recombinant Rabbit Monoclonal Antibody (9D8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

ATF5 is a protein-coding gene functioning as a transcription factor that can either stimulate or repress gene transcription by binding to DNA regulatory elements such as:

• cAMP response element (CRE): 5'-GTGACGT[AC][AG]-3'
• ATF5-specific response element (ARE): 5'-C[CT]TCT[CT]CCTT[AT]-3'
• Amino acid response element (AARE)

ATF5 plays a critical role in:

• Cell survival, proliferation, and differentiation (cell type-dependent)
• Cerebral cortex formation and neuroprogenitor cell maintenance
• Cerebellar granule neuron progenitor proliferation (via SHH pathway)
• Survival of mature olfactory sensory neurons (OSN)
• Osteogenic differentiation
• Induction of EGR1 expression with ELK1 for proliferation and survival
• Anti-apoptotic regulation through BCL2 transcription
• Hepatic CYP2B6 activation in cooperation with NR1I3/CAR
• Regulation of IL1B signaling in liver
• Activation of C/EBP family members upon IL1B stimulus
• Promotion of adipocyte differentiation with CEBPB and CEBPA
• Centrosome dynamics control and centriole–pericentriolar material interaction

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: MA5-38303_ATF5_Q9Y2D1-1_Rabbit.svg, MA5-38303_ATF5_Q9Y2D1-1_Rabbit_PDP.jpeg)