Thermo Fisher Scientific PGRP-S Monoclonal Antibody (188C424)
PGRP-S 단백질을 특이적으로 인식하는 마우스 단클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human 및 Mouse 시료 반응성. Protein G로 정제된 1.0 mg/mL 액상 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:20–1:1,000 |
| Flow Cytometry (Flow) | 1:20–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 188C424 |
| Immunogen | Synthetic peptide, KLH-conjugated, corresponding to residues 165–180 of human PGRP-S |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2161699 |
Product Specific Information
- Suggested positive control: mouse spleen lysate or protein.
Target Information
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever.
Recently, a family of proteins called peptidoglycan recognition proteins (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria.
Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and is an excellent target for recognition by the eukaryotic innate immune system.
The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver, which participates in host defense by producing acute phase proteins and clearing microorganisms from the blood.
PGRP-S is present in neutrophils and inhibits the growth of Gram-positive bacteria, functioning as a neutrophil antibacterial protein. It may also have additional functions, as it is expressed in human bone marrow at levels 50–100 times higher than in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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