Thermo Fisher Scientific PGRP-S Monoclonal Antibody (188C424)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: mouse spleen lysate or protein.

Target Information

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever.
Recently, a family of proteins called peptidoglycan recognition proteins (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria.

Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and is an excellent target for recognition by the eukaryotic innate immune system.
The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver, which participates in host defense by producing acute phase proteins and clearing microorganisms from the blood.

PGRP-S is present in neutrophils and inhibits the growth of Gram-positive bacteria, functioning as a neutrophil antibacterial protein. It may also have additional functions, as it is expressed in human bone marrow at levels 50–100 times higher than in neutrophils.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.