Thermo Fisher Scientific TEM8 Monoclonal Antibody (200C1339 (SB20))
TEM8 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료에 반응하며, Protein G로 정제된 액상 형태. TEM8 관련 암 연구 및 Bacillus anthracis 수용체 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 200C1339 (SB20) |
| Immunogen | Synthetic peptide corresponding to residues 481–497 of human TEM8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1088113 |
Product Specific Information
- Suggested positive control: TEM8 transfected cell lysate.
Target Information
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker implicated in colorectal cancer.
The encoded protein also serves as a docking receptor for Bacillus anthracis toxin, the causative agent of anthrax.
Binding of the protective antigen (PA) component of the anthrax toxin to this receptor mediates delivery of toxin components (EF and LF) into the cytosol, disrupting normal cellular processes.
Three alternatively spliced variants encoding different protein isoforms have been described.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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