Thermo Fisher Scientific LIME1 Monoclonal Antibody (OTI5D3), TrueMAB
인간 LIME1 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB 및 IHC(P) 실험에 최적화됨. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol 버퍼에 보관. T 세포 신호 조절 연구용으로 적합.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–295 of human LIME1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with an unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Csk-mediated phosphorylation of the C-terminal negative-regulatory tyrosine of LIME-associated Lck can increase enzymatic activity compared with the total Lck pool, indicating LIME acts as a positive regulator of TCR-dependent T cell signaling. Under certain conditions, LIME may also mediate inhibitory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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