Thermo Fisher Scientific DC-SIGN Monoclonal Antibody (120507)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA125615 | - | Thermo Fisher Scientific MA125615 DC-SIGN Monoclonal Antibody (120507) 100 ug pk | 재고문의 | pk | 632,000원 | - | 695,200원 |
Applications
Tested Dilution
Publications
Western Blot (WB)
1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
8-25 µg/mL
Immunocytochemistry (ICC/IF)
8-25 µg/mL
Flow Cytometry (Flow)
2.5 µg/ 10^6 cells
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse / IgG2b
Class
Monoclonal
Type
Antibody
Clone
120507
Immunogen
NIH/3T3 transfectants stably expressing human DC-SIGN1.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
IgG fraction
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_779638
Product Specific Information
MA1-25615 detects DC-SIGN from human samples.
Target Information
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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