Thermo Fisher Scientific DC-SIGN Monoclonal Antibody (120507)
인간 DC-SIGN 단백질을 검출하는 Mouse IgG2b 단클론 항체. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. NIH/3T3 세포에서 발현된 인간 DC-SIGN1을 면역원으로 제작. 액상 형태, 0.5 mg/mL 농도, 보존제 무첨가. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 8–25 µg/mL |
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg / 10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 120507 |
| Immunogen | NIH/3T3 transfectants stably expressing human DC-SIGN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | IgG fraction |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779638 |
Product Specific Information
MA1-25615 detects DC-SIGN from human samples.
Target Information
This gene encodes a transmembrane receptor commonly referred to as DC-SIGN, expressed on dendritic cells and macrophages. It plays a key role in the innate immune system, recognizing diverse pathogens such as parasites and viruses. The protein contains three domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor, binding carbohydrate ligands on microbial and host cell surfaces. The neck domain facilitates homo-oligomerization, enabling multivalent ligand binding with high avidity.
Rare variations in the number of 23 amino acid repeats in the neck domain significantly affect ligand binding.
DC-SIGN is closely related to L-SIGN (GeneID 10332) but differs in ligand-binding properties and tissue distribution.
Alternative splicing produces multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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