Thermo Fisher Scientific Thyroid Peroxidase Monoclonal Antibody (MoAb47)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:25

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MoAb47

Immunogen

Thyroid Peroxidase purified from human thyroid microsomes. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Thyroid Peroxidase,uniProtId:P07202-1,ncbiNodeId:9606,antigenRange:1-933,antigenLength:933,antigenImageFileName:MA1-25524_Thyroid_Peroxidase_P07202-1_House_mouse.svg,antigenImageFileNamePDP:MA1-25524_Thyroid_Peroxidase_P07202-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_2205893

Product Specific Information

Recommended positive controls: Thyroid.

Perform heat mediated retrieval with 1 mM EDTA buffer, pH 8.0. We suggest incubation period of 30-60 minutes at room temperature.

Target Information

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.