Thermo Fisher Scientific CATSPER1 Polyclonal Antibody
CATSPER1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간 시료에 반응하며, 합성 펩타이드(aa 300-400)를 면역원으로 제작됨. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 300–400 of human CATSPER1 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CATSPER1.
Target Information
CATSPER1 is a voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction, and chemotaxis towards the oocyte.
Activated by extracellular progesterone and prostaglandins in the following order: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2.
Progesterone activation shifts voltage dependence towards more physiological, negative membrane potentials and is not mediated by metabotropic receptors or second messengers.
Sperm capacitation enhances the effect of progesterone by providing an additional negative shift. Also activated by the elevation of intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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