Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11)
Phospho-c-Met (Tyr1234, Tyr1235) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 재현성을 제공합니다. Human 및 Mouse 시료에 반응하며, Flow Cytometry에 최적화되어 있습니다. Protein A/G로 정제되었으며, -20°C에서 보관합니다.
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MetY12341235-6F11 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745031 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
MET (c-Met) is a receptor-like tyrosine kinase associated with various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, initiating signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
Biological roles:
- Embryonic development (gastrulation, muscle and neuron formation, angiogenesis, kidney development)
- Adult functions (wound healing, organ regeneration, tissue remodeling)
Clinical relevance:
MET dysregulation is linked to gastric, renal, and breast cancers, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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