Thermo Fisher Scientific SLITRK1 Polyclonal Antibody
SLITRK1 단백질을 인식하는 Rabbit Polyclonal 항체로 인간, 마우스, 랫트에 반응합니다. Western blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 완충액에 0.02% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the center of human Slitrk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153768 |
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20470 can be used with blocking peptide PEP-0590.
Target Information
SLIT and NTRK-like family 1 (Slitrk1) is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1–6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family.
For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth.
While Slitrk1 variants have been suggested to be associated with Tourette’s Syndrome, it is thought to play only a minor role, if at all.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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