Thermo Fisher Scientific LCK Polyclonal Antibody
Rabbit polyclonal antibody targeting human LCK, suitable for WB, IHC, and ICC/IF. Recognizes residues 200–300 region of LCK. High specificity, liquid form, storage at -20°C/-80°C. For research use only.
- 카탈로그번호
- PA519422
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 200–300 of Human Lck |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985791 |
Product Specific Information
This antibody is predicted to react with chicken based on sequence homology.
Target Information
LCK is a member of the Src-family tyrosine kinases, essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates ITAM motifs in zeta subunits, creating binding sites for SH2 domains of tyrosine kinase ZAP70, which is subsequently phosphorylated and activated to generate downstream signaling via adaptor LAT.
LCK is primarily localized to the plasma membrane, with a fraction associated with the Golgi apparatus that may contribute to Raf activation under weak TCR stimulation. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2/SH3 domains mediating protein-protein interactions.
LCK also regulates apoptosis induced by various stimuli (not by death receptors). Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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