Thermo Fisher Scientific LCK Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with chicken based on sequence homology.

Target Information

LCK is a member of the Src-family tyrosine kinases, essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates ITAM motifs in zeta subunits, creating binding sites for SH2 domains of tyrosine kinase ZAP70, which is subsequently phosphorylated and activated to generate downstream signaling via adaptor LAT.
LCK is primarily localized to the plasma membrane, with a fraction associated with the Golgi apparatus that may contribute to Raf activation under weak TCR stimulation. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2/SH3 domains mediating protein-protein interactions.
LCK also regulates apoptosis induced by various stimuli (not by death receptors). Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.