Thermo Fisher Scientific Bim Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품. BCL-2 단백질군 관련 세포사멸 연구용으로 사용. 연구용 한정 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–50 of Human Bim |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2802915 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and regulate apoptosis through anti- or pro-apoptotic functions. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3) and interacts with BCL2, BCL2L1/BCL-X(L), and MCL1 to activate apoptosis. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting its role in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate BIM is an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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