Thermo Fisher Scientific Chk1 Polyclonal Antibody
Chk1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 인간, 생쥐, 랫드 반응성. 고순도(>95%) 항원 친화 크로마토그래피로 정제. DNA 손상 체크포인트 연구용으로 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 251–300 of Human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2802920 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 is a key mediator in the DNA damage-induced checkpoint network and an evolutionarily conserved kinase ensuring genomic integrity under genotoxic stress.
Inhibition of CHK1 abrogates the G2 or S checkpoint, leading p53-deficient cancer cells to mitotic catastrophe and apoptosis, while normal cells remain arrested in G1.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since about 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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