Thermo Fisher Scientific ADAMTS4 Monoclonal Antibody (OTI2G8), TrueMAB
인간 ADAMTS4 단백질(aa 296-577)에 특이적인 Mouse IgG1 단클론 항체. Western blot에 최적화되어 있으며, 동결건조 형태로 제공. PBS 버퍼(8% trehalose) 내 보존, -20°C에서 보관 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 296–577 of human ADAMTS4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The ADAMTS4 gene encodes a member of the ADAMTS protein family, characterized by domains such as a propeptide region, metalloproteinase domain, disintegrin-like domain, and thrombospondin type 1 motif.
This enzyme lacks a C-terminal TS motif and is involved in the degradation of aggrecan (a major cartilage proteoglycan) and brevican (a brain-specific extracellular matrix protein).
These activities suggest roles in arthritic disease and central nervous system processes, including glioma progression.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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