
Thermo Fisher Scientific CD45 Monoclonal Antibody (OX-1)
Rat CD45 인식 단클론 항체(OX-1)로 면역조직화학, 면역세포화학, 유세포분석 등에 사용 가능. 단백질 A로 정제된 액상 형태, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Assay-dependent
Immunocytochemistry (ICC/IF)
- Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-1 |
| Immunogen | Rat thymocyte membrane glycoproteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_928406 |
Additional Formats
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-Rat CD45 antibody, clone OX-1 recognizes CD45, also known as the leucocyte common antigen (LCA).
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of all lymphocyte surface proteins.
It is absent in non-hematopoietic cell lines and tissues. CD45 plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases and cytokine receptor signaling through JAK suppression.
Multiple isoforms exist due to alternative splicing, differing in extracellular domains while sharing identical transmembrane and cytoplasmic domains.
CD45 is essential for T- and B-cell receptor signaling, integrin-mediated signal transduction, apoptosis regulation, and various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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