Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI1E6), TrueMAB
인간 CD68 단백질을 표적으로 하는 마우스 단클론 항체로, WB 및 IHC(P) 분석에 적합. 고순도 친화 크로마토그래피 정제, 무보존제 제형. 연구용으로 사용되며 세포의 식세포 활성 및 백혈병 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–319 of human CD68 produced in SF9 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein mainly expressed in intracellular lysosomes of monocytes and macrophages. It is also found in dendritic cells and peripheral blood granulocytes. CD68 is implicated in phagocytic activities and lysosomal metabolism, as well as cell-cell and cell-pathogen interactions.
Expression is observed in interdigitating reticulum cells of the tonsil, histiocytic lymphoma, histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated CD68 expression has been reported on CD34+ cells in various human malignancies, including AML.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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