Thermo Fisher Scientific IPO5 Monoclonal Antibody (OTI3B8), TrueMAB
IPO5 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS, BSA, 글리세롤 완충액에 보관되며, -20°C에서 안정적으로 저장 가능합니다. 연구용 전용 제품입니다.
- 카탈로그번호
- TA811926
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–220 of human IPO5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nucleocytoplasmic transport is a signal- and energy-dependent process occurring through nuclear pore complexes in the nuclear envelope. Import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits (karyopherins).
Importin alpha binds the NLS-containing cargo in the cytoplasm, and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP-binding protein Ran, the complex translocates through the pore, and the importin subunits dissociate.
Importin alpha enters the nucleoplasm with its passenger protein, while importin beta remains at the pore. Interactions between importin beta and FG repeats of nucleoporins are essential for translocation through the pore complex. The protein encoded by this gene belongs to the importin beta family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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